Condition: Antibiotic Treatment · Sponsor: Rutgers, The State University of New Jersey
Antibiotics are lifesaving therapeutic drugs which have been used by adults, children, and infants alike for decades. There is an increase in global use of antibiotics over the course of lifetime and earlier in lifetime, with some countries recording as high as 12 courses a year in children younger than two. While antibiotics are successful in eradicating many pathogenic bacteria, research has demonstrated significant effect on beneficial gut microbiota, including long-lasting shift in the dynamics, composition, richness, and maturity of the intestinal flora. Microbiota alterations during early life, including through antibiotics use as well as birth via C-section, constitute a developmental perturbation, which increases the risk of modern diseases of immune and metabolic dysfunction. Strong epidemiological evidence suggests associations between early stressors of the microbiota and a number of common diseases, such as obesity, asthma, allergies, celiac disease, and Type 1 Diabetes. Furthermore, excess antibiotic exposure is associated with the development of neurological and psychiatric disorders. Currently, no strategies exist to restore the microbiome other than reliance on spontaneous repair mechanism, which often takes months in a healthy individual barring further antibiotic exposure. Contrary to popular belief, ingestion of probiotics, particularly after antibiotics, has been demonstrated to slow down the repair as it introduces an exogenous and massive amounts of only…
This description comes directly from the study's public registry record.
Maria Gloria Dominguez-Bello, PhD · 848-932-5648 · md1360@sebs.rutgers.edu
Anna Dulencin, PhD · (848) 932-8309 · anna.dulencin@eagleton.rutgers.edu
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| Rutgers Department of Biochemistry & Microbiology | New Brunswick, New Jersey, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06609980