Condition: CNI-resistant Steriod Resistant Nephrotic Syndrome · CNI-intolerent · Steriod Resistant Nephrotic Syndrome · Sponsor: The Children's Hospital of Zhejiang University School of Medicine
This exploratory clinical trial aims to evaluate the efficacy and safety of Blinatumomab in treating children with calcineurin inhibitor (CNI)-resistant or multidrug-resistant steroid-resistant nephrotic syndrome (SRNS). Eligible participants include pediatric patients aged 2 to 17 years who have either failed to respond to adequate CNI therapy or are resistant to at least two classes of immunosuppressants, including CNIs and biologics. A short course of low-dose Blinatumomab will be administered in an open-label, single-arm, self-controlled trial design. The study seeks to determine whether Blinatumomab can reduce proteinuria and induce clinical remission in this difficult-to-treat population, offering a potential new therapeutic option for children with limited response to conventional therapies.
This description comes directly from the study's public registry record.
Jianhua Mao, PhD, MD · 13516819071 · maojh88@zju.edu.cn
Xiaojing Zhang, MD · 15867172808 · 6510007@zju.edu.cn
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| Children's Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06607991