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Study identifier: NCT06607458 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

Condition: Refractory Metastatic Colorectal Cancer  ·  Sponsor: Delcath Systems Inc.

PhasePhase 2
Planned participants90
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if using a liver-directed therapy with high dose chemotherapy followed by approved cancer treatment to treat patients with colorectal cancer that has spread to the liver is safe and tolerable. The clinical trial will also learn if the liver-directed therapy with high dose chemotherapy works on the disease in the liver. Investigators will compare the use of the liver-directed therapy with high dose chemotherapy followed by approved cancer treatment or approved cancer treatment alone. Participants will: * Undergo up to two liver-directed therapy with high dose chemotherapy procedures followed by approved cancer treatment or take approved cancer treatment alone * Visit clinic at least every two weeks for checkups and tests * Complete scans approximately every two months

This description comes directly from the study's public registry record.

Talk to the study team

Matthew Cooney, MD  ·  216-374-8221  ·  MedicalMonitoring@delcath.com

Always discuss trial participation with your own doctor first.

Locations (14)

City of HopeDuarte, California, United StatesRecruiting
UCLA Hematology/Oncology-Santa MonicaSanta Monica, California, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
The University of Kansas Clinical Research CenterFairway, Kansas, United StatesRecruiting
Ochsner Clinic FoundationNew Orleans, Louisiana, United StatesRecruiting
Huntsman Cancer Institute, University of UtahSalt Lake City, Utah, United StatesRecruiting
Czech Republic - University HospitalPrague, CzechiaRecruiting
Medizinische Hochschule HannoverHanover, GermanyRecruiting
Helios Park-Klinikum LeipzigLeipzig, GermanyRecruiting
Instiuto Europeo de OncologiaMilan, ItalyRecruiting
Leiden University Medical Center (LUMC)Leiden, NetherlandsRecruiting
Clinical Hospital Center "Bezanijska Kosa"Belgrade, SerbiaRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06607458