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Study identifier: NCT06605118 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

Condition: Obstetrical Complications · Labor and Delivery Complication · Cesarean Delivery  ·  Sponsor: The George Washington University Biostatistics Center

PhasePhase 3
Planned participants8000
Who can joinFemale, N/A to no upper limit
Healthy volunteersYes

About this study

This is a phase-III multi-center double-blind randomized controlled trial of 8,000 individuals undergoing a scheduled or prelabor cesarean delivery who are randomized to either adjunctive azithromycin prophylaxis or to placebo. Both groups also will receive standard of care preoperative antibiotics (excluding azithromycin). The primary endpoint is a maternal infection composite defined as any one of the following up to 6 weeks postpartum: endometritis, wound infection, abscess, septic thrombosis, sepsis, pneumonia, pyelonephritis and breast infection.

This description comes directly from the study's public registry record.

Talk to the study team

Rebecca G Clifton, PhD  ·  301-881-9260  ·  rclifton@bsc.gwu.edu

Steven Weiner, MS  ·  weiner@bsc.gwu.edu

Always discuss trial participation with your own doctor first.

Locations (14)

University of Alabama - BirminghamBirmingham, Alabama, United StatesRecruiting
Regents of the University of California San FranciscoSan Francisco, California, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Columbia UniversityNew York, New York, United StatesRecruiting
University of North Carolina - Chapel HillChapel Hill, North Carolina, United StatesRecruiting
Duke UniversityDurham, North Carolina, United StatesRecruiting
Case Western Reserve UniversityCleveland, Ohio, United StatesRecruiting
Ohio State UniversityColumbus, Ohio, United StatesRecruiting
Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting
Magee Women's HospitalPittsburgh, Pennsylvania, United StatesRecruiting
Brown UniveristyProvidence, Rhode Island, United StatesRecruiting
Baylor College of MedicineHouston, Texas, United StatesRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06605118