Condition: Esophageal Squamous Cell Carcinoma (ESCC) · Immunotherapy · Sponsor: Sichuan University
The aim of this clinical trial is to evaluate whether low-dose involved-field radiotherapy combined with immunochemotherapy can reduce treatment-related adverse effects, enhance progression-free survival (PFS), and improve overall survival (OS) in patients with locally advanced, unresectable esophageal squamous cell carcinoma. The key questions this study seeks to address are: * Can low-dose involved-field radiotherapy combined with immunochemotherapy reduce treatment-related adverse effects? * Does this combined approach improve PFS and OS in these patients? Participants in the study will: * Undergo an endoscopy at West China Hospital to confirm their diagnosis. * Receive a treatment regimen that includes low-dose radiotherapy at 45.0 Gy in 1.8 Gy per fraction over 25 fractions, alongside immunochemotherapy, with three cycles of chemotherapy administered every 3 weeks. * After completing the full treatment regimen, participants will undergo regular follow-up visits and monitoring by healthcare professionals.
This description comes directly from the study's public registry record.
zhenyu ding, MD · +86 028-854-22562 · dingzhenyu@scu.edu.cn
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| West China Hospital of Sichuan University | Chengdu, Sichuan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06603402