Condition: Coronary Artery Disease · Atherosclerotic Plaque · Coronary Computed Tomography Angiography · Sponsor: Prof. Maurovich-Horvat Pál
INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to coronary CT angiography due to stable chest pain, followed for 24 months by using a photon-counting detector CT (PCD-CT). INTENSE Trial aims 1) to assess the effect of short-term intensified statin therapy on coronary anatomy and physiology using PCD-CT and 2) to determine the impact of short-term, intensified statin therapy on coronary plaque morphology and hemodynamics to identify statin responder and non-responder patients in addition to testing the hypothesis of "plaque memory" after the 24-month follow-up period.
This description comes directly from the study's public registry record.
Pál Maurovich-Horvat, Prof., Dr. · +36206632485 · maurovich-horvat.pal@semmelweis.hu
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| Semmelweis University, Medical Imaging Centre | Budapest, Budapest, Hungary | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06603363