Condition: Pneumonia, Community-Acquired · COVID-19 Pneumonia · Cardiovascular Diseases · Sponsor: Hellenic Institute for the Study of Sepsis
Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism) increases after infections, but causal mechanisms are not understood yet. There is an essential need for improved understanding of the relationship between pneumonia and cardiovascular diseases and early identification of patients at risk of cardiovascular events to develop tailored therapies. The overall concept underpinning "Homi-lung" is to investigate the time course of host-microbiome interactions during \& after pneumonia to i) understand the causal relationship between trained immunity, microbiome dysbiosis and cardiovascular and respiratory diseases (CVRD) progressions, ii) define endotypes of pneumonia associated with response to treatment \& CVRD history; iii) develop biomarkers to predict the individual response to the treatment \& CVRD progression, and iv) preclinically validate therapeutical approaches for CVRD during \& after pneumonia.
This description comes directly from the study's public registry record.
Prof. Evangelos Giamarellos-Bourboulis · 00302105831994 · egiamarel@med.uoa.gr
Always discuss trial participation with your own doctor first.
| 2nd Department of Internal Medicine, University General Hospital of Alexandroupolis | Alexandroupoli, Greece | Not Yet Recruiting |
| 10th Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases | Athens, Greece | Recruiting |
| 1st Department of Internal Medicine, General Hospital of Athens G. GENNIMATAS | Athens, Greece | Recruiting |
| 1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S. | Athens, Greece | Recruiting |
| 1st Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO | Athens, Greece | Recruiting |
| 1st Intensive Care Clinic of the Medical School of the University of Athens, Evangelismos General Hospital | Athens, Greece | Recruiting |
| 1st University Department of Internal Medicine, General Hospital of Athens LAIKO | Athens, Greece | Recruiting |
| 1st University Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases | Athens, Greece | Recruiting |
| 2nd Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO | Athens, Greece | Recruiting |
| 2nd Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases | Athens, Greece | Recruiting |
| 3rd University Department of Internal Medicine, Sotiria Athens Hospital of Chest Diseases | Athens, Greece | Recruiting |
| 4th Department of Internal Medicine, ATTIKON University General Hospital | Athens, Greece | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06601998