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Study identifier: NCT06601933 Synced from ClinicalTrials.gov · July 29, 2026
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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

Condition: Mild Cognitive Impairment (MCI) · Cognitive Training  ·  Sponsor: Columbia University

PhasePhase 2
Planned participants240
Who can joinAll sexes, 55 Years to 89 Years
Healthy volunteersNo

About this study

Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high dose crosswords (4 puzzles per week) to low dose crosswords (1 puzzle per week) and a health education control group on the cognition and function of participants.

This description comes directly from the study's public registry record.

Talk to the study team

Lola Nedic, BA  ·  6467747202  ·  ln2563@cumc.columbia.edu

Davangere P Devanand, MD, MBBS  ·  6467748658  ·  dpd3@cumc.columbia.edu

Always discuss trial participation with your own doctor first.

Locations (4)

University of Miami Miller School of MedicineMiami, Florida, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesRecruiting
Duke University Medical CenterDurham, North Carolina, United StatesRecruiting
University of WashingtonSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06601933