Condition: Intracranial Infections · Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
This clinical trial aims to compare two methods of administering polymyxin B for treating severe brain infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB). The two methods are: 1) delivering polymyxin B directly into the brain (intracranial administration) and 2) combining this with an intravenous (IV) infusion. The goal is to determine which approach is more effective in clearing the infection, improving patient outcomes, and influencing the concentration of polymyxin B in the cerebrospinal fluid (CSF). Participants in this study will be monitored for both effectiveness and safety, with a focus on CSF polymyxin B levels, to find the best treatment strategy for these challenging infections.
This description comes directly from the study's public registry record.
huifang jiang, master · +8613567147275 · fangfang93@zju.edu.cn
yangmin hu, Master
Always discuss trial participation with your own doctor first.
| The Second Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Recruiting |
| Ningbo Medical Center Lihuili Hospital | Ningbo, Zhejiang, China | Recruiting |
| The First Affiliated Hospital of Wenzhou Medical University | Wenzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06595979