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Study identifier: NCT06590025 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study the Efficacy and Safety of the INtegral Cognitive REMediation Program (INCREM) for Depression

Condition: Depression · Depressive Disorder  ·  Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

PhasePhase 3
Planned participants296
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Feeling sad about negative or stressful events has nothing to do with the diagnosis of depression, as this is a very prevalent mental illness among the population with devastating consequences for the person suffering from it. Symptoms range from mood swings, extreme sadness, apathy, inability to feel pleasure, to sleep problems, eating disorders, physical problems, and more. Other very common but little-known symptoms are those that affect memory, concentration, and the ability to organize and solve problems. Recent scientific findings have shown that these symptoms, called cognitive symptoms, are the most interfering with day-to-day life, even when other mental symptoms begin to improve or have resolved. Cognitive symptoms are associated with work difficulties, especially in terms of productivity or a decrease in social relationships to the point of isolation, thus interfering with the full recovery from depression. Studies have estimated that the economic and social costs not related to the health costs of depression can be more than 90 million euros per year. The fact that cognitive symptoms are not explored during clinical interviews means that they are not treated adequately, and professionals usually wait for cognitive difficulties to be resolved with the available antidepressant treatments. But more than 30% of people with depression are unable to return to work, and up to 45% of patients are on sick leave a year later, although mood symptoms have often been ameliora…

This description comes directly from the study's public registry record.

Talk to the study team

Alejandra Espinosa, Dr.  ·  +34935537791  ·  aespinosag@santpau.cat

UICEC  ·  +34679057557  ·  uicec@santpau.cat

Always discuss trial participation with your own doctor first.

Locations (1)

Institut de Recerca de l'Hospital de la Santa Creu i Sant PauBarcelona, Catalonia, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT06590025