Condition: Metastatic Head and Neck Squamous Cell Carcinoma · Metastatic Hypopharyngeal Squamous Cell Carcinoma · Metastatic Laryngeal Squamous Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back after a period of improvement (recurrent) and/or that has spread from where it first started (primary site) to other places in the body (metastatic). Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of tumor cells. This may help keep tumor cells from growing. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Giving cetuximab and pembrolizumab together may be more effective at treating patients with recurrent and/or metastatic HNSCC than pembrolizumab alone.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Recruiting |
| Fremont - Rideout Cancer Center | Marysville, California, United States | Terminated |
| VA Palo Alto Health Care System | Palo Alto, California, United States | Recruiting |
| UCHealth Memorial Hospital Central | Colorado Springs, Colorado, United States | Recruiting |
| Memorial Hospital North | Colorado Springs, Colorado, United States | Recruiting |
| Poudre Valley Hospital | Fort Collins, Colorado, United States | Recruiting |
| Cancer Care and Hematology-Fort Collins | Fort Collins, Colorado, United States | Recruiting |
| Lutheran Hospital - Cancer Centers of Colorado | Golden, Colorado, United States | Recruiting |
| UCHealth Greeley Hospital | Greeley, Colorado, United States | Recruiting |
| Medical Center of the Rockies | Loveland, Colorado, United States | Recruiting |
| Mount Sinai Medical Center | Miami Beach, Florida, United States | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, United States | Recruiting |
+ 180 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06589804