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Study identifier: NCT06588855 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

Condition: Moderately to Severely Active Ulcerative Colitis  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants350
Who can joinAll sexes, 16 Years to 80 Years
Healthy volunteersNo

About this study

This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative colitis (UC).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: GA45330 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. and Canada)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (200)

Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - DothanDothan, Alabama, United StatesRecruiting
Mayo Clinic HospitalScottsdale, Arizona, United StatesRecruiting
Arizona Digestive Health, P.C (ADH)Sun City, Arizona, United StatesRecruiting
Om Research LLCApple Valley, California, United StatesRecruiting
Valley View Internal MedicineGarden Grove, California, United StatesRecruiting
Gastro Care AssociatesLancaster, California, United StatesRecruiting
University of Southern CaliforniaLos Angeles, California, United StatesRecruiting
Hoag Memorial Hospital Presbyterian;Hoag Center for Research and EducationNewport Beach, California, United StatesRecruiting
Stanford Medicine Outpatient CenterRedwood City, California, United StatesRecruiting
Peak Gastroenterology AssociatesColorado Springs, Colorado, United StatesRecruiting
Hi Tech and Global Research, LLCCoral Gables, Florida, United StatesRecruiting
The Sister Life ResearchHialeah, Florida, United StatesRecruiting

+ 188 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06588855