Condition: Multiple Myeloma · Autologous Stem Cell Transplantation · Sponsor: Augusta University
Patients who receive a chemotherapy called melphalan are at high risk of having nausea and vomiting. A medication called olanzapine has been shown to decrease nausea and vomiting after chemotherapy. A previous research study found the 10 mg dose of olanzapine (combined with 3 standard medications used routinely to prevent nausea/vomiting) to be effective for patients who received melphalan chemotherapy, but several other studies have shown many patients have a side effect of sleepiness (e.g., sedation) with that dose of the medication. Our study will compare two lower doses of olanzapine (5 mg and 2.5 mg) in combination with the 3 standard medications used to prevent nausea/vomiting in the patients who receive melphalan chemotherapy to determine which dose is effective in preventing nausea and vomiting with the lowest amount of sleepiness side effect.
This description comes directly from the study's public registry record.
Amber Clemmons, PharmD, BCOP, FHOPA · 706-721-6493 · aclemmons@augusta.edu
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| Wellstar MCG | Augusta, Georgia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06588413