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Study identifier: NCT06585982 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Synbiotics Impact on Insulin and TNF-α in MAFLD: a Gut Microbiota Profile Analysis

Condition: Fatty Liver Disease  ·  Sponsor: Universitas Diponegoro

PhaseNA
Planned participants50
Who can joinAll sexes, 25 Years to 55 Years
Healthy volunteersNo

About this study

Primary Objective: To analyze the effect of synbiotic supplementation on metabolic profile, insulin and TNF-α and gut microbiota changes in patients with Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD). Research question: Are there any changes in metabolic profile, Insulin and TNF-α and gut microbiota changes in MAFLD patients after synbiotic supplementation Participants will: * Treatment group given supplementation and the control group will be given placebo at a dose of 2x1 tablet for 12 weeks. * Patients will visit the hospital every 28 days for up to 4 months for control and follow-up supplementation. * patients will be given a supplement consumption compliance logbook and a food record logbook used to record food consumption filled in by the patient.

This description comes directly from the study's public registry record.

Talk to the study team

Hery D Purnomo, Dr  ·  +628122803136  ·  herydjagat@yahoo.co.id

Adiyan Pramono, PhD  ·  +6281282037051  ·  adriyanpramono@fk.undip.ac.id

Always discuss trial participation with your own doctor first.

Locations (1)

RSUP Dr. KariadiSemarang, Semarang, IndonesiaRecruiting

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Source record: clinicaltrials.gov/study/NCT06585982