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Study identifier: NCT06585410 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Condition: Cutaneous Squamous Cell Carcinoma (CSCC)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants369
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will test a study drug called cemiplimab to see if it can help treat early-stage Cutaneous Squamous Cell Carcinoma (CSCC), a type of skin cancer. Cemiplimab works by helping the immune system to kill cancer cells. It binds to a protein called Programmed cell Death-1 (PD-1) on the surface of certain immune cells. The main purpose of this study is to compare how well cemiplimab works compared to surgery, when injected into the lesion. The study is looking at: * The side effects cemiplimab might cause * How well cemiplimab works compared to surgery

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (52)

Medical Dermatology Specialists - PhoenixPhoenix, Arizona, United StatesRecruiting
Mayo Clinic - ArizonaScottsdale, Arizona, United StatesRecruiting
University of Arizona Cancer CenterTucson, Arizona, United StatesRecruiting
Arkansas Research TrialsNorth Little Rock, Arkansas, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Profound Research, Dermatology Medical Group - OceansideOceanside, California, United StatesRecruiting
Stanford UniversityRedwood City, California, United StatesRecruiting
Peak Dermatology, Aesthetics and WellnessVisalia, California, United StatesRecruiting
George Washington University Medical Faculty AssociatesWashington D.C., District of Columbia, United StatesRecruiting
Life Clinical TrialsCoral Springs, Florida, United StatesRecruiting
Dermatology Associates of the Palm Beaches, Integri Research at Dermatology AssociatesDelray Beach, Florida, United StatesRecruiting
University of South FloridaTampa, Florida, United StatesRecruiting

+ 40 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06585410