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Study identifier: NCT06584604 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation

Condition: Intensive Care Unit · Mechanical Ventilation · Critical Illness  ·  Sponsor: Leiden University Medical Center

PhaseN/A
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Calibration of the esophageal balloon catheter (Pes catheter) is important for the right measurement of the esophageal pressure (Pes) and subsequent interpretation of the derived transpulmonary pressures during mechanical ventilation. Both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. Therefore one should calibrate the balloon to determine the best filling pressure. Calibration of the Pes catheter has only been validated in mandatory ventilation but not in support modes in which the patient triggers the ventilator and is supported by the mechanical ventilator. Because the forces in the thoracic cage behave differently in comparison with a controlled mode, it is to be expected that the calibration process in a support mode yields different filling volumes in comparison with the calibration process in a controlled mode. This would lead to a more reliable filling volume in support mechanical ventilation and a more reliable derivation of transpulmonary pressure and therefore to a better treatment of patients.

This description comes directly from the study's public registry record.

Talk to the study team

Willem Snoep, BSc  ·  +31 (0)71-5262164  ·  j.w.m.snoep@lumc.nl

Abraham Schoe, MD, PhD  ·  a.schoe@lumc.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Leiden University Medical CenterLeiden, South Holland, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06584604