Condition: Encephalitis · Encephalitis, Viral · Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody · Sponsor: Tongji Hospital
Based on the records of traditional Chinese medicine, CBS has the functions of purifying the heart, eliminating phlegm, stimulating bile secretion, and soothing the nerves. It has the ability to alleviate fever, coma, delirium, epilepsy, convulsions in youngsters, dental caries, throat swelling, mouth ulcers, carbuncle, and furuncle. Encephalitis is a neurological condition characterized by widespread or multiple inflammation of brain tissue. The causes of encephalitis are many and can stem from infectious organisms or be induced by autoimmune reactions, the latter being referred to as autoimmune encephalitis (AE). The yearly occurrence rate of encephalitis is 12.6 per 100,000 individuals. Among these cases, approximately 40-50% are caused by infectious factors, whereas 20-30% are attributed to autoimmune encephalitis (AE). The development of viral encephalitis involves the direct invasion of brain tissue by the virus and the immune response of the body to viral antigens. The virus multiplies extensively, leading to the degeneration of neurons, necrosis, the proliferation of glial cells, and the infiltration of inflammatory cells. These severe tissue reactions can result in the formation of demyelinating lesions and damage to blood vessels and the areas surrounding them. Additionally, vascular lesions affect the circulation in the brain and worsen the damage to brain tissue. The development of AE involves several factors, including molecular mimicry, the activation of latent…
This description comes directly from the study's public registry record.
Ke Shang, MD · 86-27-83663337 · kay_sang@qq.com
Ke Shang, MD · 86-27-83663477 · kay_sang@hust.edu.cn
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| Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology | Wuhan, Hubei, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06584045