Condition: Metastatic Prostate Cancer · Sponsor: Fundacion Oncosur
The purpose of this clinical trial is to determine the anti-tumor activity of talazoparib plus enzalutamide as first line treatment for metastatic castration resistant prostate cancer (mCRPC) in participants whose disease has progressed on abiraterone. The main questions it aims to answer are: * Does talazoparib plus enzalutamide improve efficacy in metastatic castration resistant prostate cancer (mCRPC) compared to enzalutamide alone? * What is the time to disease progression \[radiographic, Prostate Specific Antigen (PSA), clinical\] in participants treated with talazoparib plus enzalutamide after progression on abiraterone? * What medical problems do participants have when receiving talazoparib plus enzalutamide? Researchers will compare the combination of talazoparib and enzalutamide as a first-line treatment for mCRPC to see if the combination improves the PSA response rate and delays progression compared to enzalutamide alone. The safety and tolerability of the combination (talazoparib and enzalutamide) will also be studied
This description comes directly from the study's public registry record.
Luis Gonzaga Paz-Ares Rodríguez · +34 91 560 82 27 · info@oncosur.org
Elena Castro, Dra. · 627213615 · ecastro.imas12@h12o.es
Always discuss trial participation with your own doctor first.
| Institut Català d'Oncologia (ICO) | Badalona, Barcelona, Spain | Recruiting |
| Consorcio Corporación Sanitaria Parc Taulí | Sabadell, Barcelona, Spain | Recruiting |
| Hospital Universitario Marqués de Valdecilla | Santander, Cantabria, Spain | Recruiting |
| Hospital Universitario de Jerez de la Frontera | Cadiz, Cádiz, Spain | Recruiting |
| Hospital Universitario Cruces | Barakaldo, Vizcaya, Spain | Recruiting |
| Hospital Universitario Del Mar. | Barcelona, Spain | Recruiting |
| Hospital Clínico y Provincial de Barcelona | Barcelona, Spain | Recruiting |
| Hospital Clínico San Carlos | Madrid, Spain | Recruiting |
| Hospital 12 de Octubre | Madrid, Spain | Recruiting |
| Hospital Universitario La Paz | Madrid, Spain | Recruiting |
| Hospital Universitario Virgen de la Victoria | Málaga, Spain | Recruiting |
| Hospital Universitario Miguel Servet | Zaragoza, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06582628