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Study identifier: NCT06581939 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU

Condition: Mechanical Ventilation  ·  Sponsor: Nantes University Hospital

PhaseNA
Planned participants830
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The NUTRIREA-4 trial will test the hypothesis that an individually tailored rehabilitation program combining nutritional therapy, physiotherapy, and physical activity and started early in the ICU then continued uninterruptedly throughout the post-ICU stay and at home after hospital discharge improves the long-term outcomes of critical-illness survivors, compared to usual care. From ICU admission to recovery at home, the trial patients will receive either usual care or the early extended rehabilitation program. Usual care will consist in nutritional support and physiotherapy according to usual local practice in each participating ICU. The early extended program will consist of nutritional therapy, physiotherapy, and physical activity according to a standardized protocol tailored to general- and muscle-health improvements achieved in each individual patient over time.

This description comes directly from the study's public registry record.

Talk to the study team

Diane MAUGARS  ·  +33(0)253482473  ·  diane.maugars@chu-nantes.fr

Carole OUISSE  ·  +33(0)244768205  ·  carole.ouisse@chu-nantes.fr

Always discuss trial participation with your own doctor first.

Locations (52)

CH d'AlbiAlbi, FranceRecruiting
CHU d'Amiens - Site SudAmiens, FranceRecruiting
CHU d'AmiensAmiens, FranceRecruiting
CHU d'AngersAngers, FranceRecruiting
CH d'AngoulèmeAngoulême, FranceRecruiting
CH d'ArgenteuilArgenteuil, FranceRecruiting
CH de BelfortBelfort, FranceRecruiting
CHU de BesançonBesançon, FranceRecruiting
CH de BéthuneBéthune, FranceRecruiting
CHU de Bordeaux - Hôpital PellegrinBordeaux, FranceRecruiting
Centre Hospitalier William MoreyChalon-sur-Saône, FranceRecruiting
CH de CholetCholet, FranceRecruiting

+ 40 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06581939