Condition: Patellofemoral Osteoarthritis · Sponsor: University Hospital, Basel, Switzerland
ENCANTO is a randomized, controlled, multi-center phase II clinical trial for the treatment of patellofemoral osteoarthritis (PFOA) with an Advanced Therapy Medicinal Product (ATMP), nasal chondrocyte-based tissue engineered cartilage (N-TEC) implantation in comparison with current standard of care depending on the stage of osteoarthritis. The goal of this phase II trial is to evaluate the efficacy of N-TEC treatment in comparison to an active comparator Autologous Matrix Induced Chondrogenesis (AMIC) for early stage PFOA or patellofemoral arthroplasty (PFA) for late stage PFOA. The N-TEC engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane.
This description comes directly from the study's public registry record.
Marcus Mumme, MD · +41 44 387 29 77 · marcus.mumme@usb.ch
Gyözö Lehoczky, MD · +41 61 704 2615 · Gyözö.Lehoczky@ukbb.ch
Always discuss trial participation with your own doctor first.
| Orthopedic Hospital Vienna-Speising | Vienna, Austria | Recruiting |
| University Hospital Sveti Duh | Zagreb, Croatia | Not Yet Recruiting |
| Evangelisches Waldkrankenhaus Spandau | Berlin, Germany | Not Yet Recruiting |
| Orthopedic Clinic König-Ludwig-Haus | Würzburg, Germany | Recruiting |
| IRCCS Ospedale Galeazzi-Sant'Ambrogio | Milan, Italy | Recruiting |
| Fondazione Policlinico Universitario Campus Bio-Medico | Rome, Italy | Not Yet Recruiting |
| Maastricht University Medical Center | Maastricht, Netherlands | Not Yet Recruiting |
| Zeromski hospital | Krakow, Poland | Recruiting |
| Department of Orthopaedics, University of Gothenburg (UGOT) | Mölndal, Sweden | Recruiting |
| University Hospital Basel | Basel, Switzerland | Recruiting |
| Crossklinik | Basel, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06576583