Condition: Bladder Cancer · Muscle-Invasive Bladder Carcinoma · Sponsor: Columbia University
The goal of this clinical trial is to learn if gemcitabine/cisplatin plus cemiplimab with or without fianlimab works to treat bladder cancer in adults. The main question it aims to answer is: Can gemcitabine, cisplatin, and cemiplimab with or without fianlimab treat bladder cancer? Participants will be randomly selected (like the loss of a coin) to treatment with gemcitabine, cisplatin, cemiplimab, and fianlimab or gemcitabine, cisplatin, and cemiplimab. Participants will: * Undergo transurethral resection of bladder tumor (TURBT) followed by the start of treatment, receive 4 cycles of treatment (21 day cycles) * After 4 cycles of treatment, patients will undergo repeat maximal TURBT with imaging * Participants with a complete response will continue maintenance cemiplimab or cemiplimab/fianlimab for 13 more cycles with imaging every 3 months * Participants without a complete clinical response will undergo cystectomy (bladder surgery).
This description comes directly from the study's public registry record.
Alexander Z Wei, MD · 212-305-5874 · aw3056@cumc.columbia.edu
Nurse Navigator · 212-305-5098 · cancerclinicaltrials@cumc.columbia.edu
Always discuss trial participation with your own doctor first.
| Columbia University Irving Medical Center/ New York Presbyterian Hospital | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06571708