Condition: Ischemic Stroke · Sponsor: Insel Gruppe AG, University Hospital Bern
DO-IT is an international, multicenter, prospective, two-arm, randomized, open label, blinded endpoint superiority trial determining the safety and efficacy of intravenous thrombolysis (IVT) in participants experiencing an acute ischemic stroke (AIS) with recent (within the last 48 hours) intake of direct oral anticoagulant (DOAC). For this purpose, 906 adult participants experiencing an AIS with recent DOAC intake will be enrolled at several high-volume international stroke centers and randomly assigned in a ratio of 1:1 to one of two treatment arms: (1) IVT and standard of care/best medical treatment or (2) standard of care/best medical treatment. The DO-IT trial is a definitive test of the hypothesis that IVT is superior to standard of care for achieving better outcome at 90 days in AIS participants with recent DOAC intake.
This description comes directly from the study's public registry record.
Thomas Meinel, MD, PhD · +41 31 66 4 25 67 · thomas.meinel@insel.ch
Freschta Zipser-Mohammadzada, PhD · +41 31 63 2 60 83 · nctu@insel.ch
Always discuss trial participation with your own doctor first.
| UZ Leuven | Leuven, Belgium | Not Yet Recruiting |
| Hamilton Health Sciences | Hamilton, Ontario, Canada | Not Yet Recruiting |
| GHU Paris Psychiatrie et Neurosciences, Sainte Anne | Paris, France | Not Yet Recruiting |
| Heidelberg University Hospital | Heidelberg, Germany | Not Yet Recruiting |
| "Attikon" University Hospital | Athens, Greece | Not Yet Recruiting |
| National Cerebral and Cardiovascular Center Osaka | Osaka, Kansai, Japan | Not Yet Recruiting |
| Academic Medical Center Amsterdam, Department of Neurology | Amsterdam, Netherlands | Not Yet Recruiting |
| Canterbury District Health Board | Christchurch, New Zealand | Not Yet Recruiting |
| Akershus Hospital | Oslo, Norway | Not Yet Recruiting |
| Lisbon Central University Hospital Centre | Lisbon, Portugal | Not Yet Recruiting |
| Vall d'Hebron Stroke Center | Barcelona, Spain | Not Yet Recruiting |
| University Hospital Basel | Basel, Switzerland | Not Yet Recruiting |
+ 2 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06571149