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Study identifier: NCT06570213 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD

Condition: PTSD  ·  Sponsor: Rush University Medical Center

PhaseEARLY_Phase 1
Planned participants270
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to understand if we can improve the treatment for posttraumatic stress disorder (PTSD). We are looking into whether the combination of Stellate Ganglion Block (SGB) treatment and Cognitive Processing Therapy (CPT) can reduce symptoms of PTSD. CPT is a trauma-focused talk therapy that can help identify and challenge unhelpful trauma-related beliefs about oneself, others, and the world. It is known to be a highly effective talk therapy for PTSD. SGB treatment is a procedure involving an injection of local anesthetic into a bundle of nerves located in the neck that is part of the sympathetic nervous system which controls our body's response to stressful situations and blocks pain. The proposed project will systematically test whether combining CPT with SGB produces greater PTSD symptom reductions and functional improvements in the short- and longer-term up to 6-months follow-up compared to CPT (+Placebo) or SGB (+Daily Monitoring) alone.

This description comes directly from the study's public registry record.

Talk to the study team

Philip Held, PhD  ·  312-942-1423  ·  philip_held@rush.edu

Sarah Pridgen, MA  ·  312-563-0577  ·  sarah_pridgen@rush.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Rush University Medical CenterChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06570213