Condition: Hypertension · Primary Aldosteronism · Hypokalemia · Sponsor: Jens Titze
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy. The investigators hypothesize that patients with primary aldosteronism have excessive Na+ storage in the muscle, which can now be quantified non-invasively using 23NaMRI. In analogy to the role of HbA1c as a metabolic long-term marker in diabetes, the quantifiable changes in muscle Na+ content may deliver the data evidence necessary to justify and conduct randomized diagnostic endpoint outcome trials in the future, with the ultimate aim to improve PA detection rate and treatment.
This description comes directly from the study's public registry record.
Tzy Tiing Lim · +65 6516 7666 · tzytiing.lim@duke-nus.edu.sg
Marton Adriana, MD · adriana.marton@duke-nus.edu.sg
Always discuss trial participation with your own doctor first.
| Singapore General Hospital | Singapore, Singapore | Not Yet Recruiting |
| Duke NUS Medical School | Singapore, Singapore | Recruiting |
| Changi General Hospital | Singapore, Singapore | Recruiting |
| Sengkang General Hospital | Singapore, Singapore | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06569589