Condition: Hypercholesterolemia · Sponsor: VA Office of Research and Development
Statins are the most cost-effective medications to lower cholesterol and cardiovascular disease (CVD) risk. However, many patients at high-risk for CVD do not accept or adhere to statins. This gap in patient's use of statins limits the full impact of these effective medications resulting in higher cholesterol levels and CVD risk. The main barriers to using statins are patients' perceived lack of benefit, excess risk of statin toxicity as well as their misperceptions of their CVD risk. Statin pharmacogenomic testing - an application of precision medicine - is a readily available, feasible, and inexpensive intervention that addresses this barrier by using genetic testing to identify the nearly 1 out of 2 patients with enhanced benefit and/or reduced risk of statin toxicity or increased risk for CVD. By communicating statin pharmacogenomic test results to Veterans at high-risk for CVD not taking statin therapy, the investigators aim to improve patients' perceptions of their risk of CVD and statins and, in turn, their acceptance of and adherence to statins to reduce their cholesterol levels and CVD risk.
This description comes directly from the study's public registry record.
Deepak Voora, MD · (919) 286-0411 · deepak.voora@va.gov
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| Richard L. Roudebush VA Medical Center, Indianapolis, IN | Indianapolis, Indiana, United States | Recruiting |
| Durham VA Medical Center, Durham, NC | Durham, North Carolina, United States | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06568601