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Study identifier: NCT06568484 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB

Condition: Tuberculosis, Latent  ·  Sponsor: Johns Hopkins University

PhasePhase 2/Phase 3
Planned participants2530
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

A seamless, staged Phase II/III, open-label, multicenter, non-inferiority trial, to compare the efficacy and safety of 4 weeks of bedaquiline (BDQ) versus a a standard regimen for preventing regimen for preventing confirmed or probable tuberculosis disease (TBD) during 72 weeks of follow-up among people living with HIV (PLHIV) and high-risk Close Contacts (CC) of adults with Drug Susceptible (DS) or Rifampin Resistant (RR) TB.

This description comes directly from the study's public registry record.

Talk to the study team

Bonnie S. King, MHS  ·  4106249189  ·  bking6@jh.edu

Kate Boehner, RN, MSN  ·  2012592222  ·  kate.b@jhu.edu

Always discuss trial participation with your own doctor first.

Locations (6)

HNSEB (Hospital Nacional Sergio E. Bernales)Lima, PeruNot Yet Recruiting
SES PoliclinicoLima, PeruNot Yet Recruiting
Kilimanjaro Clinical Research InstituteMoshi, TanzaniaRecruiting
Joint Clinical Research CentreKampala, UgandaRecruiting
Makerere Lung InstituteKampala, UgandaNot Yet Recruiting
MU-JHU Care Ltd.Kampala, UgandaRecruiting

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Source record: clinicaltrials.gov/study/NCT06568484