Condition: Obstructive Sleep Apnea · Surgery · Dexmedetomidine · Sponsor: Peking University First Hospital
Patients with obstructive sleep apnea (OSA) are at increased risk of developing sleep disturbances after surgery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, analgesic, and anxiolytic effects. Ketamine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. Esketamine is the S-enantiomer of racemic ketamine and twice as potent as racemic ketamine for analgesia. A recent trial showed that mini-dose esketamine-dexmedetomidine in combination with opioids improved analgesia and subjective sleep quality after scoliosis correction surgery. This trial is designed to test the hypothesis that mini-dose dexmedetomidine-esketamine supplemented analgesia may improve postoperative sleep quality in patients at high-risk of OSA.
This description comes directly from the study's public registry record.
Xin-Quan Liang, M.D. · +86 152 1084 6532 · liangxinquan09@163.com
Dong-Xin Wang, M.D. · 8610 83572784 · wangdongxin@hotmail.com
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| Peking University First Hospital | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06566482