Condition: Tracheal Intubation · Video Laryngoscopy · Remifentanil · Sponsor: Nordsjaellands Hospital
Globally, we are approaching 1 million surgical procedures each day. Tracheal intubation is the mainstay of securing the patient's airway and breathing during general anaesthesia. Approximately 100.000 tracheal intubations are performed annually in Denmark. Airway management remains the primary reason for anaesthesia-related morbidity and mortality. It has been traditionally accepted that best tracheal intubation conditions are obtained by paralysing the patient's muscles, including vocal cords, using a neuromuscular blocking agent (NMBA) such as rocuronium. However, using NBMA may increase the risk of pulmonary complications, intra-operative awareness, in which the patient is paralysed but awake during surgery, anaphylaxis, and re-intubation. In addition, there is a risk of residual neuromuscular blockade postoperatively. In the US, prolonged ventilation and unplanned intubation are the top two most costly perioperative complications. An alternative to NMBA is a large dose of opioids to depress laryngeal reflexes during intubation. The most commonly used non-NMBA modality includes bolus administration of remifentanil. However, remifentanil may cause bradycardia and hypotension. Even short periods of hypotension have been shown to increase the risk of myocardial injury and other serious adverse events such as renal failure, delirium, and even mortality. Evidence also indicates that intubation conditions using only opioids to facilitate intubation, including remifentanil, are…
This description comes directly from the study's public registry record.
Anders K Nørskov, PhD · 48292510 · anders.kehlet.noerskov@regionh.dk
Lars H Lundstrøm, PhD · 48296512 · lars.hyldborg.lundstroem.02@regionh.dk
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| Department of Anesthesiology, NOH, Rigshospitalet | Copenhagen, Denmark | Recruiting |
| Department of Anesthesiology, North Zeeland Hospital | Hillerød, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06564857