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Study identifier: NCT06563479 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

Condition: HPV-Related Squamous Cell Carcinoma  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 3
Planned participants291
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to find out if a personalized approach to chemoradiation therapy (which may include a lower dose of radiation) is as effective as the standard chemoradiation therapy in people with HPV-positive throat cancer. Other purposes of this study include looking at the following: * Whether a lower dose of radiation in combination with standard chemotherapy causes fewer side effects than the standard dose of radiation therapy in combination with standard chemotherapy * How the study approaches (lower dose of radiation therapy + standard chemotherapy and standard dose of radiation therapy + standard chemotherapy) affect participants' quality of life. The researchers will measure quality of life by having participants fill out questionnaires.

This description comes directly from the study's public registry record.

Talk to the study team

Nancy Lee, MD  ·  212-639-3341  ·  leen2@mskcc.org

Nadeem Riaz, MD  ·  646-888-3495

Always discuss trial participation with your own doctor first.

Locations (9)

Hartford Healthcare (Data Collection Only)Hartford, Connecticut, United StatesRecruiting
Baptist Alliance MCI (Data Collection Only)Miami, Florida, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06563479