Condition: Classical Hodgkin Lymphoma · Child · Adolescent · Sponsor: Children's Cancer Group, China
Generally, pediatric patients tolerate acute toxicities but are vulnerable to late effects. Thus, increasing chemotherapy intensity to achieve more rapid complete early response to limit radiation therapy is worth testing. In this CCCG-HL-2024 study, Brentuximab vedotin (Bv) was used to replace VCR and bleomycin in the ABVE-PC regimen in the previous CCCG-HD-2018 study, respectively, to form a Bv-AEPC regimen for the treatment of newly diagnosed classic Hodgkin lymphoma (cHL) in children, adolescents and young adults. On the premise of maintaining a 4-year event free survival (EFS)\>90% in the low-, intermediate-and high-risk groups, increase the early assessment complete response rate (the overall early complete response rate increased by 20%, that is, from 54.0% to 74.0%) to further reduce the proportion of children receiving radiotherapy to benefit them.
This description comes directly from the study's public registry record.
YI JIN GAO, MD · 86-21-38087513 · gaoyijin@scmc.com.cn
JIE ZHAO · zhaojie@scmc.com.cn
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| Shanghai Children's Medical Center | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06563245