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Study identifier: NCT06561360 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

Condition: Hairy Cell Leukemia  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants86
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to compare the safety of vemurafenib in combination with obinutuzumab to the standard of approach of cladribine in combination with rituximab. The researchers will look at which treatment causes fewer or milder side effects. Researchers think vemurafenib and obinutuzumab (non-chemotherapy drugs) may cause fewer side effects compared with the usual approach of chemotherapy drugs. They will also compare the two approaches to see which approach is more effective at eliminating cancer cells.

This description comes directly from the study's public registry record.

Talk to the study team

Jae Park, MD  ·  646-608-3743  ·  parkj6@mskcc.org

Mark Geyer, MD  ·  646-608-3745

Always discuss trial participation with your own doctor first.

Locations (10)

Dana Farber Cancer InstituteBoston, Massachusetts, United StatesNot Yet Recruiting
Mayo Clinic Cancer CenterRochester, Minnesota, United StatesNot Yet Recruiting
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Commack - Suffolk (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (All Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Uniondale, New York, United StatesRecruiting
Ohio State UniversityColumbus, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06561360