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Study identifier: NCT06559306 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

Condition: Depressive Disorder, Major  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants752
Who can joinAll sexes, 18 Years to 74 Years
Healthy volunteersNo

About this study

The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (205)

University of Alabama at BirminghamBirmingham, Alabama, United StatesCompleted
Chandler Clinical TrialsChandler, Arizona, United StatesCompleted
University of ArizonaTucson, Arizona, United StatesRecruiting
SanRo Clinical Research Group LLC WCG Clinical NetworkBryant, Arkansas, United StatesRecruiting
Preferred Research PartnersLittle Rock, Arkansas, United StatesCompleted
PAMOJA Clinical Institute LLCAnaheim, California, United StatesRecruiting
Axiom ResearchColton, California, United StatesRecruiting
Elite Research Network 6Encino, California, United StatesCompleted
Behavioral Research Specialists LLCGlendale, California, United StatesCompleted
WR PRI Los AlamitosLos Alamitos, California, United StatesCompleted
Excell Research IncOceanside, California, United StatesRecruiting
Prospective Research Innovations IncRancho Cucamonga, California, United StatesCompleted

+ 193 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06559306