Condition: Acute Ischemic Stroke · Anterior Circulation Brain Infarction · Sponsor: Capital Medical University
For patients with acute ischemic stroke caused by large vessel occlusion, endovascular thrombectomy has been demonstrated to be the most effective therapy, as approximately 90% of the occluded vessels can be recanalized. However, less than 50% of patients could achieve functional independence, and over 15% died 90 days after stroke. Although the mismatch of successful recanalization with poor prognosis can be attributed to many factors, the infarct core formed during thrombectomy and reperfusion injury after thrombectomy may be among the most important and effective neuroprotective strategies urgently needed. Remote ischemic conditioning (RIC) is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs. In the transient focal cerebral ischemia-reperfusion model, the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size. Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia, this patient population is akin to the model of transient focal cerebral ischemia-reperfusion. Furthermore, a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy. However, whether remote ischemic conditioning could provide…
This description comes directly from the study's public registry record.
Xunming Ji, MD, PhD · 010-8319-9439 · jixm@ccmu.edu.cn
Sijie Li, MD · +8613581610258 · lisijie@xwh.ccmu.edu.cn
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| Suzhou Municipal Hospital of Anhui Province | Suzhou, Anhui, China | Recruiting |
| Taihe County People's Hospital | Taihe Chengguanzhen, Anhui, China | Recruiting |
| Tongling People's Hospital | Tongling, Anhui, China | Recruiting |
| Beijing Luhe Hospital affiliated to Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Beijing Fangshan District First Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Fujian Provincial Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| Zhangzhou Municipal Hospital of Fujian Province | Zhangzhou, Fujian, China | Recruiting |
| Shenzhen Second People's Hospital | Shenzhen, Guangdong, China | Not Yet Recruiting |
| South China Hospital Affiliated to Shenzhen University | Shenzhen, Guangdong, China | Recruiting |
| The Second Nanning People's Hospital | Nanning, Guangxi, China | Recruiting |
| Cangzhou Central Hospital | Cangzhou, Hebei, China | Recruiting |
| Army Medical University Noncommissioned Officer School Affiliated Hospital | Shijiazhuang, Hebei, China | Recruiting |
+ 44 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06559241