Condition: Ischemic Stroke · Sponsor: Insel Gruppe AG, University Hospital Bern
DO-IT is an international, prospective observational registry evaluating whether the administration of intravenous thrombolysis (IVT) is safe and improves functional outcome in ischemic stroke patients with recent direct oral anticoagulant (DOAC) intake. For this purpose, information on 2800 adult participants experiencing an acute ischemic stroke will be obtained at several high-volume international stroke centers and divided into three groups: IVT with recent DOACs intake (DOAC+IVT), and recent DOAC intake not receiving IVT (DOAC) as well as anonymized patients without DOAC receiving IVT. The patients are followed up for 90 days after the index event. treatment recommendations from the described observations. The investigators hypothesize that also more liberal decisions for IVT in patients with recent DOAC intake are not associated with an increased risk for symptomatic intracerebral hemorrhage (sICH) and result in better functional outcome at 3 month.
This description comes directly from the study's public registry record.
Thomas Meinel, MD, PhD · +41 31 66 4 25 67 · thomas.meinel@insel.ch
Freschta Zipser-Mohammadzada, PhD · +41 31 63 2 60 83 · nctu@insel.ch
Always discuss trial participation with your own doctor first.
| Medical University of Innsbruck | Innsbruck, Austria | Not Yet Recruiting |
| Cliniques Universitaires Saint Luc | Brussels, Belgium | Not Yet Recruiting |
| UZ Leuven | Leuven, Belgium | Not Yet Recruiting |
| The University of British Columbia | Vancouver General Hospital | Vancouver, Canada | Not Yet Recruiting |
| CHU Caen | Caen, France | Not Yet Recruiting |
| Nordwest-Krankenhaus Sanderbusch | Sanderbusch, Germany | Not Yet Recruiting |
| Universitäsklinikum Tübingen | Tübingen, Germany | Not Yet Recruiting |
| Dept. of Medicine, University of Thessaly | Larissa, Thessaly, Greece | Recruiting |
| A.O.R.N. Antonio Cardarelli Hospital | Naples, Italy | Not Yet Recruiting |
| Ospedali Riuniti Hospital | Palermo, Italy | Not Yet Recruiting |
| Ospedale "Bufalini", Cesena | Perugia, Italy | Recruiting |
| AUSL-IRCCS di Reggio Emilia | Reggio Emilia, Italy | Not Yet Recruiting |
+ 21 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06556446