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Study identifier: NCT06554613 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Olanzapine Impact on First-line Immunotherapy for Advanced EGFR-negative NSCLC

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: Second Affiliated Hospital of Nanchang University

PhasePhase 2
Planned participants156
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

Clinical Trial The objective of this clinical trial is to determine whether antidepressant medications, such as olanzapine, in combination with immune checkpoint inhibitors are more effective than the use of immune checkpoint inhibitors alone. The main questions it aims to answer are: Is the combination therapy of antidepressant medication with immune checkpoint inhibitors more efficacious than the therapy with immune checkpoint inhibitors alone? What medical issues might participants encounter when treated with the combination of antidepressant medication and immune checkpoint inhibitors? Participants will: Take olanzapine in combination with immune checkpoint inhibitors or immune checkpoint inhibitors alone for 2 months. Visit the clinic for check-ups and tests every two weeks, and have follow-up visits every six weeks after the treatment ends. Keep a record of their symptoms and disease progression.

This description comes directly from the study's public registry record.

Talk to the study team

Huang Long, Director  ·  +86 13699549060  ·  huanglongdoctor@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

The Second Affiliated Hospital of Nanchang UniversityNanchang, Jiangxi, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06554613