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Study identifier: NCT06551220 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy of Trastuzumab Deruxtecan in Metastatic Breast Cancer With Different HER2 Expression Patterns

Condition: Metastatic Breast Cancer  ·  Sponsor: Sun Yat-sen University

PhaseN/A
Planned participants800
Who can joinFemale, 18 Years to 80 Years
Healthy volunteersNo

About this study

The purpose of this observational study is to learn about the HER2 heterogeneity and its impact on benefit from trastuzumab deruxtecan in metastatic breast cancer. The main question it aims to answer is: \- Does the heterogeneity of HER2 expression level and spatial distribution in different tissues affect the efficacy of trastuzumab deruxtecan in metastatic breast cancer?

This description comes directly from the study's public registry record.

Talk to the study team

Xiaoming Xie, MD, PhD  ·  86-020-87343806  ·  xiexm@sysucc.org.cn

Yutian Zou, MD, PhD  ·  86-020-87343806  ·  zouyt@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (26)

Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Dana-Farber Cancer Institute, Harvard Medical SchoolBoston, Massachusetts, United StatesRecruiting
Fujian Cancer Hospital, Fujian Medical UniversityFuzhou, Fujian, ChinaRecruiting
The 10th Affiliated Hospital of Southern Medical UniversityDongguan, Guangdong, ChinaRecruiting
The First People's Hospital of FoshanFoshan, Guangdong, ChinaRecruiting
The Sixth Affiliated Hospital, School of Medicine, South China University of Technology.Foshan, Guangdong, ChinaRecruiting
Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaRecruiting
The Affiliated Panyu Central Hospital, Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
Guangdong Provincial Hospital of Chinese MedicineGuangzhou, Guangdong, ChinaRecruiting
The Affiliated Cancer Hospital, Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou, Guangdong, ChinaRecruiting

+ 14 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06551220