Condition: Circadian Rhythm Sleep Disorder of Shift Work Type · Metabolic Disease · Insulin Sensitivity · Sponsor: Colorado State University
People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D risk are unknown. This project will examine whether elevated plasma lipids are a mechanism by which circadian misalignment impairs vascular function, insulin sensitivity, glucose homeostasis and muscle lipid accumulation, which could be targeted to prevent and treat cardiometabolic disease in people who chronically experience circadian misalignment, which includes more than 20% of the US workforce.
This description comes directly from the study's public registry record.
Josiane L Broussard, PhD · 9704913103 · josiane.broussard@colostate.edu
Ellen Lyon, MS · 9704913103 · ellen.lyon@colostate.edu
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| Colorado State University | Fort Collins, Colorado, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06550115