Condition: Acute Ischemic Stroke · Cerebral Infarction · Sponsor: Capital Medical University
Stroke is the second leading cause of death worldwide, and ischemic stroke is the most frequent type. Intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 hours of symptom onset is the most effective therapy for patients with acute ischemic stroke. However, ischemic stroke progression and early reocclusion are not an uncommon phenomenon in patients after intravenous thrombolysis, resulting in neurological deterioration, which is associated with unfavorable functional outcomes. The underlying mechanism mainly involves the augmented platelet activation, triggered by the activated coagulation cascade during thrombolysis, which peaks within 2 hours of initiating rt-PA administration. Therefore, early antiplatelet therapy following intravenous thrombolysis represents a promising therapeutic approach to prevent neurological deterioration and improve the functional outcome of patients treated with intravenous thrombolysis. Currently, guidelines recommend initiating antiplatelet therapy 24 hours after intravenous thrombolysis due to the potential risk of increased bleeding. The safety and efficacy of early antiplatelet treatment following intravenous thrombolysis in patients with acute ischemic stroke remain clear. The study aims to test the hypothesis that in patients with acute ischemic stroke treated with intravenous thrombolysis, early administration of oral aspirin will improve functional outcomes without increasing the risk of intracranial hemorrh…
This description comes directly from the study's public registry record.
XunMing Ji, MD, PD · 010-8319-9439 · jixm@ccmu.edu.cn
Wenbo Zhao, MD, PD · 010-8319-9048 · zhaowb@xwh.ccmu.edu.cn
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| The Third The People's Hospital Of Bengbu | Bengbu, Anhui, China | Recruiting |
| Suzhou municipal hospital | Suzhou, Anhui, China | Recruiting |
| Xuanwu Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Aerospace central hospital | Haidian, Beijing Municipality, China | Recruiting |
| Beijing Pinggu District Hospital | Pinggu, Beijing Municipality, China | Recruiting |
| Beijing Luhe Hospital affiliated to Capital Medical University | Tongzhou, Beijing Municipality, China | Recruiting |
| Fujian university affiliated provincial hospital | Fuzhou, Fujian, China | Recruiting |
| The First Affiliated Hospital Of Xiamen University | Xiamen, Fujian, China | Recruiting |
| Xiamen Xinglin hospital | Xiamen, Fujian, China | Not Yet Recruiting |
| Zhangzhou Hospital of Fujian Province | Zhangzhou, Fujian, China | Recruiting |
| Brain Hospital Affiliated to Guangzhou Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Guigang people's hospitalv | Guigang, Guangxi, China | Recruiting |
+ 59 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06548971