Condition: Cryopyrin Associated Periodic Syndrome · Familial Cold Urticaria · Muckle-Wells Syndrome · Sponsor: Hospices Civils de Lyon
Circadian rhythms are characterized by the physiology's adaptation to the alternation of day and night, enabling to adapt to the environment. These rhythms are generated by a molecular clock within each cell. At the molecular level, the circadian clock is based on a complex system of cell-autonomous transcription loops. These exert positive and negative feedback on themselves, generating cyclic transcriptional activity. * In the main loop, the BMAL1 transcription factor links with CLOCK or NPAS2 ( (Neuronal PAS Domain Protein 2) to activate transcription of per1,2 and 3 and cryptochrome (cry1 and cry2), which in turn repress BMAL1/CLOCK1 transcriptional activity.. The BMAL1/CLOCK complex also activates transcription of numerous target genes (per and cry, Rev-erb, etc.).. * other secondary loops refine the function of the first. Recent studies suggest that many aspects of innate immunity are controlled by circadian rhythm through inhibition of NLRP3 inflammasome activation. Nevertheless, the regulation of the NLRP3 inflammasome by the circadian clock has yet to be elucidated. Inflammasomes are molecular platforms that control caspase-1 activation and consequently the maturation of precursors of (interleukine) IL-1β, pro-IL-18, a pro-inflammatory cytokine. Since its discovery, its functions have been widely characterized as part of the innate immune response as a sensor of pathogens and danger signals (extracellular ATP (Adenosine triphosphate), atmospheric pollutants). NLRP3…
This description comes directly from the study's public registry record.
Alexandre Alexandre, PR · 04 27 85 61 26 · Alexandre.belot@chu-lyon.fr
Samira Plassart · 04 27 85 54 42 · Samira.plassart@chu-lyon.fr
Always discuss trial participation with your own doctor first.
| Hôpital Femme-Mère-Enfant (HCL) | Bron, France | Recruiting |
| Hôpital Claude Huriez (CHU de Lille) | Lille, France | Not Yet Recruiting |
| Hôpital de la Croix-Rousse (HCL) | Lyon, France | Not Yet Recruiting |
| Hôpital Edouard Herriot (HCL) | Lyon, France | Not Yet Recruiting |
| Hôpital Tenon (AP-HP) | Paris, France | Not Yet Recruiting |
| Hôpital Kremlin-Bicêtre (AP-HP) | Paris, France | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06544018