Condition: AKI - Acute Kidney Injury · Sponsor: Mahidol University
This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane. This membrane offers the added benefit of absorbing inflammatory cytokines. In vitro studies show that vancomycin is reduced by around 20 percent in patients using the AN69ST membrane, which is part of the oXiris membrane's structure. However, there is currently a lack of in vivo studies demonstrating the impact of the oXiris membrane on vancomycin levels. Therefore, the hypothesis of this study is that vancomycin is also reduced by absorption in the oXiris membrane. This study measures the levels of vancomycin in these patients to determine the pharmacokinetic parameters.
This description comes directly from the study's public registry record.
chidtawan Hirunsomboon, PharmD · +66-988309558 · chidtawan.hir@mahidol.ac.th
Always discuss trial participation with your own doctor first.
| Facullty of Pharmacy Mahidol University | Bangkok, Payathi, Thailand | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06543940