Condition: Acute Coronary Syndrome · Sponsor: CHA University
The previous Mono Antiplatelet and Colchicine Therapy (MACT) pilot study (NCT04949516) demonstrated that it was feasible to discontinue aspirin therapy and administer low-dose colchicine on the day after percutaneous coronary intervention (PCI) in addition to potent P2Y12 inhibitors in patients with acute coronary syndrome (ACS). However, the efficacy and safety of MACT have not yet been investigated. The goal of this clinical trial is to evaluate the clinical outcomes of ticagrelor P2Y12 inhibitor monotherapy combined with colchicine immediately after PCI in patients with ACS. The main questions it aims to answer are: * What is the frequency of the composite endpoint of cardiovascular death, nonfatal spontaneous myocardial infarction, nonfatal ischemic stroke, unplanned hospitalization leading to urgent revascularization, and major bleeding at 12 months post-intervention? * What is the frequency of stent thrombosis at 12 months post-intervention? For pre-specified analyses, researchers will compare MACT to less than 1 month, 3-month, and 12-month dual antiplatelet therapy (individual patient data from the T-PASS \[NCT03797651\] and TICO \[NCT02494895\] trials) to determine if MACT is effective in treating ACS. Participants will: * Take low-dose colchicine in addition to ticagrelor maintenance therapy, discontinuing aspirin the day after PCI. * Take a high-sensitivity C-reactive protein (hs-CRP) test 1 month after PCI. * Discontinue colchicine if the hs-CRP level is less …
This description comes directly from the study's public registry record.
Hwa-In Kim · 82-31-780-5858 · niawhz23@gmail.com
Always discuss trial participation with your own doctor first.
| CHA Bundang Medical Center | Seongnam-si, Gyeonggi-do, South Korea | Recruiting |
| Keimyung University Dongsan Hospital | Daegu, South Korea | Recruiting |
| Wonkwang University Hospital | Iksan, South Korea | Recruiting |
| Myongji Hospital | Ilsan, South Korea | Recruiting |
| National Health Insurance Service Ilsan Hospital | Ilsan, South Korea | Recruiting |
| Seoul National University Bundang Hospital | Seongnam, South Korea | Recruiting |
| Ewha Womans University Seoul Hospital | Seoul, South Korea | Recruiting |
| Gangnam Severance Hospital | Seoul, South Korea | Recruiting |
| Wonju Severance Christian Hospital | Wŏnju, South Korea | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06543082