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Study identifier: NCT06542250 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Condition: B-cell Malignancies  ·  Sponsor: AstraZeneca

PhasePhase 1/Phase 2
Planned participants174
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (31)

Research SiteLa Jolla, California, United StatesRecruiting
Research SiteBoston, Massachusetts, United StatesWithdrawn
Research SiteRochester, Minnesota, United StatesNot Yet Recruiting
Research SiteHackensack, New Jersey, United StatesRecruiting
Research SiteNew York, New York, United StatesRecruiting
Research SiteNew York, New York, United StatesRecruiting
Research SiteCharlotte, North Carolina, United StatesRecruiting
Research SiteWinston-Salem, North Carolina, United StatesRecruiting
Research SiteHouston, Texas, United StatesRecruiting
Research SiteSeattle, Washington, United StatesRecruiting
Research SiteMelbourne, AustraliaRecruiting
Research SiteNedlands, AustraliaRecruiting

+ 19 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06542250