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Study identifier: NCT06541704 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

Condition: Age-related Macular Degeneration (AMD) · Geographic Atrophy (GA)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants975
Who can joinAll sexes, 50 Years to 85 Years
Healthy volunteersNo

About this study

This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead). The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) are in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (218)

Barnet Dulaney Perkins Eye Center-OphthamalogyChandler, Arizona, United StatesRecruiting
Barnet Dulaney Perkins Eye CenterPhoenix, Arizona, United StatesRecruiting
Associated Retina ConsultantsPhoenix, Arizona, United StatesRecruiting
Retinal Research InstitutePhoenix, Arizona, United StatesRecruiting
Retina Macula Institute of ArizonaScottsdale, Arizona, United StatesRecruiting
Retina Associates of TuscanTucson, Arizona, United StatesRecruiting
Retina Partners of Northwest Arkansas, PLLCSpringdale, Arkansas, United StatesRecruiting
Retina Vitreous Associates Medical GroupBeverly Hills, California, United StatesRecruiting
Retina Specialists of Beverly Hills- Department of OphthalmologyBeverly Hills, California, United StatesRecruiting
The Retina PartnersEncino, California, United StatesCompleted
Eye Medical Center of FresnoFresno, California, United StatesRecruiting
Retina Consultants of Orange CountyFullerton, California, United StatesCompleted

+ 206 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06541704