Condition: Neuroblastoma · Ewing Sarcoma · Osteosarcoma · Sponsor: Milton S. Hershey Medical Center
The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors. An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone or in combination with any drug, for the condition or illness it is being used to treat. The goals of this part of the study are: * Establish a recommended dose of silmitasertib in combination with chemotherapy * Test the safety and tolerability of silmitasertib in combination with chemotherapy in subjects with cancer * To determine the activity of study treatments chosen based on: * How each subject responds to the study treatment * How long a subject lives without their disease returning/progressing
This description comes directly from the study's public registry record.
BCC Enroll · 7175310003 · BCCEnroll@pennstatehealth.psu.edu
Always discuss trial participation with your own doctor first.
| University of Alabama/Children's of Alabama | Birmingham, Alabama, United States | Recruiting |
| Phoenix Children's Hospital | Phoenix, Arizona, United States | Recruiting |
| UCSF Benioff Children's Hospital Oakland | Oakland, California, United States | Recruiting |
| Rady Children's Hospital | San Diego, California, United States | Recruiting |
| Connecticut Children's Hospital | Hartford, Connecticut, United States | Recruiting |
| University of Florida | Gainesville, Florida, United States | Recruiting |
| Nicklaus Children's Hospital | Miami, Florida, United States | Recruiting |
| Arnold Palmer Hospital for Children | Orlando, Florida, United States | Recruiting |
| All Children's Hospital Johns Hopkins Medicine | St. Petersburg, Florida, United States | Recruiting |
| St. Joseph's Children's Hospital | Tampa, Florida, United States | Recruiting |
| Kapiolani Medical Center for Women and Children | Honolulu, Hawaii, United States | Recruiting |
| Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine | Louisville, Kentucky, United States | Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06541262