Condition: Neuroendocrine Neoplasms · Sponsor: University Hospital, Antwerp
The CollectNET 2.0 by BE-FORCE is a prospective, multicentric, interventional study in which liquid biopsies will be collected from neuroendocrine neoplasms (NEN) patients to create an extensive biobank that will be used for current and future circulating cell-free DNA (ccfDNA) analyses. Two sampling groups will be created: the "Regular Sampling Group" and the "Intensive Sampling Group". Upon participation, up to four additional blood tubes (max. total of 32.5mL) will be collected at each timepoint as specified below. These include 3 Streck Cell-Free DNA tubes (10 mL each) which will be used for the extraction of ccfDNA and 1 PreAnalytiX (PAXgene)® Blood RNA tube (2.5 mL). All NEN patients in one of the participating hospitals who have measurable tumor burden on imaging will be asked to participate in our study and will be included in the "Regular Sampling Group". If additionally, the patient is (i) diagnosed with a histologically confirmed NEN of World Health Organisation (WHO) 2019 grade 1-3 neuroendocrine tumor (NET) or neuroendocrine carcinoma (NEC) from pancreatic, colorectal or small intestinal origin and (ii) is starting any kind of 1st line systemic treatment (e.g. somatostatin analogues, targeted therapy, chemotherapy, etc.), they will be followed up more intensively as per the "Intensive Sampling Group". If during follow-up in this "Intensive Sampling Group" patients have disease progression or have completed follow-up for 3 years in this group, their follow-up will…
This description comes directly from the study's public registry record.
Siddharth Chhajlani · 03436 · siddharth.chhajlani@uantwerpen.be
isolde Van der Massen · 03821 · netwerkstudies@uza.be
Always discuss trial participation with your own doctor first.
| AZ Rivierenland | Rumst, Antwerp, Belgium | Not Yet Recruiting |
| VITAZ | Sint-Niklaas, East-Flanders, Belgium | Not Yet Recruiting |
| University Hospital Leuven | Leuven, Flemish Brabant, Belgium | Not Yet Recruiting |
| Ziekenhuis Netwerk Antwerpen (ZNA) | Antwerp, Belgium | Not Yet Recruiting |
| Gasthuiszusters Ziekenhuizen (GZA) | Antwerp, Belgium | Not Yet Recruiting |
| AZ Monica | Antwerp, Belgium | Not Yet Recruiting |
| AZ Klina | Brasschaat, Belgium | Not Yet Recruiting |
| Antwerp University Hospital (UZA) | Edegem, Belgium | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06541080