Condition: Neuroblastoma · Sponsor: Giselle Sholler
The purpose of this study is to evaluate the investigational drug, tipifarnib (a pill taken by mouth), in combination with the Food and Drug Administration (FDA) approved drug, naxitimab, administered intravenously (IV; a liquid that continuously goes into your body through a tube that has been placed during a surgery into one of your veins). Naxitamab is FDA approved for pediatric patients 1 year of age and older and adult patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow who have demonstrated a partial response, minor response, or stable disease to prior therapy, it may not be approved in the type of disease used in this study. The goals of this part of the study are: * Test the safety and tolerability of tipifarnib in combination with naxitimab in patients with cancer * To determine the activity of study treatments chosen based on: * How each subject responds to the study treatment * How long a subject lives without their disease returning/progressing
This description comes directly from the study's public registry record.
BCC Enroll · 7175310003 · BCCEnroll@pennstatehealth.psu.edu
Always discuss trial participation with your own doctor first.
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Recruiting |
| Connecticut Children's Hospital | Hartford, Connecticut, United States | Recruiting |
| Nicklaus Children's Hospital | Miami, Florida, United States | Recruiting |
| Arnold Palmer Hospital for Children | Orlando, Florida, United States | Recruiting |
| Kapiolani Medical Center for Women and Children | Honolulu, Hawaii, United States | Recruiting |
| Cardinal Glennon Children's Medical Center | St Louis, Missouri, United States | Recruiting |
| Duke University | Durham, North Carolina, United States | Recruiting |
| Randall Children's Hospital | Portland, Oregon, United States | Recruiting |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Hershey, Pennsylvania, United States | Recruiting |
| Monroe Carrell Jr. Children's Hospital at Vanderbilt | Nashville, Tennessee, United States | Recruiting |
| Dell Children's Blood and Cancer Center | Austin, Texas, United States | Recruiting |
| Children's Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06540963