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Study identifier: NCT06536517 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.

Condition: Fibroid Uterus  ·  Sponsor: Johns Hopkins University

PhasePhase 2
Planned participants100
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

Currently, there is a nationwide epidemic of opioid abuse and overdose deaths. One source of excess opioids is overprescribing in the postoperative period. This study aims to find the optimal pain medication plan during and after laparoscopic hysterectomy to eliminate long-term opioid use. Given the increasing opioid abuse and over-prescription post-operatively, an effort should be made to determine whether one time dosing of Methadone, a longer opioid analgesics, intra-operatively is an adequate potential in treating postoperative pain after hysterectomy surgeries. The investigators hypothesize that this could minimize the need for additional post-operative and outpatient opioid prescriptions and decrease the adverse effects that are associated with the consumption, including new opioid abuse. Intervention group will receive methadone intraoperatively while the other group would receive short-acting opioids (standard).

This description comes directly from the study's public registry record.

Talk to the study team

Mostafa Borahay, MD, MBA, PhD  ·  410-550-0337  ·  mboraha1@jhmi.edu

Always discuss trial participation with your own doctor first.

Locations (2)

The Johns Hopkins Bayview Medical CenterBaltimore, Maryland, United StatesRecruiting
The Johns Hopkins HospitalBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06536517