Condition: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Sponsor: NRG Oncology
This phase II trial compares the effectiveness of adding BMX-001 to usual symptom management versus usual symptom management alone for reducing oral mucositis in patients who are receiving chemoradiation for head and neck cancer. Oral mucositis (inflammation and mouth sores) is a common side effect of chemoradiation that can cause pain and difficulty swallowing. Usual management of these side effects typically consists of using mouth rinses and pain medications during treatment and for several weeks after completion of treatment. BMX-001 neutralizes harmful substances in the body, preventing damage to macromolecules such as DNA and minimizes free radical-related toxicity in normal tissues. Adding BMX-001 to usual symptom management may be more effective than usual symptom management alone at reducing oral mucositis in patients receiving chemoradiation for head and neck cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Arizona Center for Cancer Care - Gilbert | Gilbert, Arizona, United States | Recruiting |
| Arizona Center for Cancer Care-Peoria | Peoria, Arizona, United States | Recruiting |
| Arizona Center for Cancer Care - Phoenix | Phoenix, Arizona, United States | Recruiting |
| Arizona Center for Cancer Care - Scottsdale | Scottsdale, Arizona, United States | Recruiting |
| Arizona Center for Cancer Care-Surprise | Surprise, Arizona, United States | Recruiting |
| Arizona Center for Cancer Care | Tempe, Arizona, United States | Recruiting |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, United States | Recruiting |
| Keck Medicine of USC Buena Park | Buena Park, California, United States | Suspended |
| UC San Diego Health System - Encinitas | Encinitas, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Los Angeles General Medical Center | Los Angeles, California, United States | Suspended |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | Suspended |
+ 141 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06532279