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Study identifier: NCT06532006 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

Condition: Gastroesophageal-junction Cancer · Monoclonal Antibody · Gastric Cancer  ·  Sponsor: Shanghai Henlius Biotech

PhasePhase 3
Planned participants550
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a double-blind, randomized, multiregion, comparative phase Ⅲ clinical study designed to evaluate the efficacy and safety of HLX22 in combination with trastuzumab and chemotherapy as first-line treatment in patients with HER2-positive locally advanced/metastatic adenocarcinoma of the gastric and/or gastroesophageal junction (G/GEJ).Eligible subjects will be randomized to the two groups based on a 1:1 ratio. Enrolled subjects shall be treated with the study drug until the loss of clinical benefit, death, intolerable toxicity, withdrawal of informed consent, or other reasons specified by the protocol (whichever occurs first).

This description comes directly from the study's public registry record.

Talk to the study team

Ying Li  ·  +86 18810366427  ·  ying_li1@henlius.com

Always discuss trial participation with your own doctor first.

Locations (208)

Los Angeles Cancer NetworkAnaheim, California, United StatesRecruiting
OPN - Oncology Physician Network (Los Alamitos)Los Alamitos, California, United StatesRecruiting
Banner MD Anderson Cancer CenterGreeley, Colorado, United StatesRecruiting
Advanced Research LLCDeerfield Beach, Florida, United StatesRecruiting
Florida Cancer Specialist - SouthFort Myers, Florida, United StatesRecruiting
BRCR Medical CenterPlantation, Florida, United StatesRecruiting
Napa ResearchPompano Beach, Florida, United StatesRecruiting
Florida Cancer Specialist - NorthSt. Petersburg, Florida, United StatesRecruiting
Florida Cancer Specialist - EastWest Palm Beach, Florida, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting
Mission Cancer + Blood (Exigent Network)Des Moines, Iowa, United StatesRecruiting

+ 196 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06532006