Condition: Acute Kidney Injury · Sponsor: The University of Texas Health Science Center, Houston
The investigators propose a single-center, randomized, controlled trial to determine whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease acute kidney injury (AKI) for trauma patients presenting with hemorrhagic shock compared to routine timing of initiation of PPI. Kidney injury will be assessed by the urinary kidney injury biomarkers, and the incidence, severity and AKI-free days within first week and major adverse kidney events (MAKE) at day 30. The specific aims of the study will be achieved by a cohort of 100 patients to receive either early(study) or routine (control) administration of pantoprazole for 2 days after the initial injury insult.
This description comes directly from the study's public registry record.
Yafen Liang, MD · 713-500-6226 · yafen.liang@uth.tmc.edu
Simon Betancourt Escobar, MD · 346-383-2859 · simon.betancourtescobar.1@uth.tmc.edu
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| Memorial Hermann Texas Medical Center | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06531642